Off-target analysis


Ark Therapeutics was developing a gene therapy for cancer. They had a lead molecule targeting a specific gene and hoped to find out if there were any unwanted off-target effects.


We developed a combined sequence analysis and gene expression pipeline that categorized genes into targets, secondary targets and off-targets.


The categorization of differentially expressed genes showed how the gene regulation cascade was due to silencing of the primary target, and that the therapy had no significant off-target effects.

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