Yeast ploidy analysis

Learn about how a research organization successfully outsourced computational analyses in the development of a genomically modified yeast strain.

VTT Technical Research Centre of FInland is a globally networked multitechnological applied research organization. VTT provides high-end technology solutions and innovation services.

Problem

VTT Technical Research Centre of Finland Ltd. was working on the development of industrial yeasts. In order to reliably modify a yeast genome, they had to determine the copy numbers of all of its genes.

Solution

We developed a custom analysis pipeline to infer gene copy numbers from read fraction information. From this information we estimated the ploidy of each chromosomal segment.

Outcome

The ploidy information was successfully used to guide genomic modifications.

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